陈振夏 博士 教授 博士生导师
Zhen-Xia Chen, Ph.D., Professor, PhD Supervisor
地址：基因楼418
Address: Gene Building 418, No.1 Shizishan Street Hongshan District, Wuhan, Hubei Province 430070
E-mail: zhen-xia.chen AT mail.hzau.edu.cn
研究方向 （RESEARCH INTEREST）
两性间的表型差异主要由差异表达基因（即性别偏爱性基因）引起。性别偏爱性基因中包含大量的长链非编码RNA（lncRNA）基因。虽然已经发现一些性别偏爱性lncRNA具有调控性腺发育等重要功能，但是大部分仍然功能未知。本实验室以往的研究证实利用高通量表达数据注释非编码功能元件的可靠性，并揭示性别相关驱动力对动物基因组中非编码序列演化的作用。然而，尽管已发现一些性别偏爱性lncRNA可以调控性别发育，但尚有许多仍然功能未知。
目前本课题组的研究主要围绕性别偏爱性lncRNA基因展开，运用高通量测序技术，结合遗传学、分子生物学、发育生物学、演化生物学和生物信息学等手段，对斑马鱼、青鳉鱼、鸡、人等多物种基因组中性别偏爱性lncRNA基因进行系统地识别，并对其起源与演化机制、在性别发育中的功能以及对疾病发生的影响进行深入研究。其研究结果将有助于认识性别偏爱性lncRNA基因的功能，并对实施针对不同性别患者的个性化医疗方案这一目标的实现有重要的指导意义。
本实验室真诚欢迎热爱科学、擅长学习和乐于合作的本科生、研究生、博士生、博士后和其他科研人员的加入。
Sex dimorphism in phenotype is mainly caused by genes differentially expressed between sexes (called sex-biased genes). Many sex-biased genes are genes that encode long noncoding RNAs (lncRNA). Although some sex-biased lncRNAs have been found to regulate gonad development, the function of most lncRNAs are still unknown. Our previous study validated the transcriptome annotation of noncoding functional elements, and suggested the contribution of sex-related drives in the evolution of noncoding sequences in animal genomes. Although some sex-biased lncRNAs were found to be involved in sex development, the function of most sex-biased lncRNAs were still unknown. We thus focus on sex-biased lncRNAs, systematically identifying sex-biased lncRNAs in multiple animal species (including fruitfly, zebrafish, medaka, chicken, human, and etc.) with high-throughput sequencing techniques, and exploring their evolutionary mechanisms, functions in sex development, and potential effects on diseases. The implementation of our study will provide a solid foundation for revealing the function of sex-biased lncRNAs, and be important for precision medicine.
We sincerely welcome the participation of undergraduates, postgraduates, doctoral students, postdoctoral fellows and other scientific researchers who love science and are good at learning and cooperating.
教育经历 (EDUCATION)
2006-2011 北京大学 mgm4858am美高梅集团生物信息中心 理学博士学位
Ph.D, Bioinformatics, Center for Bioinformatics, College of Life Sciences, Peking University, Beijing, China. Dissertation: Deficiency of X-linked inverted duplicates in Drosophila melanogaster and the underlying mechanisms. Mentor: Dr. Manyuan Long. 2006 - 2011
2002-2006 mgm4858am美高梅集团 mgm4858am美高梅集团 国家生命科学与技术人才培养基地 理学学士学位
Bachelor of Science, Biotechnology, National life science and technology talents training base, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China. 2002 - 2006
2003-2006 武汉大学 新闻传播学院学院 新闻学 文学学士学位
Bachelor of Arts, Journalism, School of Journalism and Communication, Wuhan University, Wuhan, Hubei, China. 2003 - 2006
工作经历 (WORK EXPERIENCE)
2016-至今 mgm4858am美高梅集团 教授
Professor, College of Life Sciences & Technology, Huazhong Agricultural University, Wuhan, China. 2016.9-Present
2011-2016 美国国立卫生研究院 消化、糖尿病、肾脏病研究所 博士后
Postdoc, Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States. Mentor: Dr. Brian Oliver. 2011.9 - 2016.9
教学 (TEACHING COURSES)
演化生物学
Evolutionary Biology
生物信息学
Bioinformatics (http://www.icourses.cn/sCourse/course_6509.html)
生命科学导论
Introduction to Life sciences (http://www.icourse163.org/course/HZAU-1001967007)
所获荣誉 (ACADEMIC AND PROFESSIONAL HONORS)
主讲课程获国家精品在线开放课程，2018.
National Excellent Online Open Course, Ministry of Education of the People's Republic of China, 2018
微课《达尔文与生物演化理论》获“2017年全国高校生命科学类微课教学比赛三等奖”。
Third prize, National University Micro Lesson Teaching Competition (Life sciences), 2017.
青年教师讲课竞赛二等奖，mgm4858am美高梅集团，2017.
Second prize, Young Teachers’ Teaching Competition, College of Life Science and Technology, Huazhong Agricultural University, 2017.
杰出科学家奖，美国国立卫生研究院学生学者联谊会，2016.
Distinguished Scientist Award, 2016 NIHCSSA Annual Symposium, Bethesda, Maryland, 2016.
女科学家旅行奖，第十届国际基因组学大会，2015.
Women Scientists Travel Awards, The 10th International Conference on Genomics, Shenzhen, Guangzhou, China, 2015.
北京大学优秀博士学位论文，北京大学，2011.
Excellent Doctoral Dissertation, Peking University, Beijing, China, 2011.
北京大学优秀毕业生，北京大学，2011.
Outstanding Graduate, Peking University, Beijing, China, 2011.
湖北省大学生优秀科研成果二等奖，湖北省，2006.
2nd Place. University Students’ Outstanding Achievements in Scientific Research, Hubei Province, China, 2006.
发表文章 (PUBLICATIONS)
基因组演化和计算生物学科研论文
Research Reports on Genomic Evolution and Computational Biology
Luo ZH, Shi MW, Yang Z, Zhang HY*, Chen ZX*. pyMeSHSim: an integrative python package to realize biomedical named entity recognition, normalization and comparison (Submitted).
Gao C, Chen L, Tang SB, Long QY, He JL, Zhang NA, Shu HB, Chen ZX, Wu M*, Li LY*. The epigenetic landscapes of histone modifications on HSV-1 genome in human THP-1 cells. Antiviral research 176, 104730, doi:10.1016/j.antiviral.2020.104730 (2020).
Chen L, Wang L, Cheng Q, Tu YX, Yang Z, Li RZ, Luo ZH, Chen ZX*. Anti-masculinization induced by aromatase inhibitors in adult female zebrafish. BMC genomics 21, 22, doi:10.1186/s12864-019-6437-z (2020).
Shi MW#, Zhang NA#, Shi CP, Liu CJ, Luo ZH, Wang DY, Guo AY*, Chen ZX*. SAGD: a comprehensive sex-associated gene database from transcriptomes. Nucleic acids research 47, D835-D840, doi:10.1093/nar/gky1040 (2019).
Chen ZX*, Oliver B, Zhang YE, Gao G, Long M*. Expressed Structurally-stable Inverted Duplicates in Mammalian Genomes as Functional Noncoding Elements. Genome biology and evolution, doi:10.1093/gbe/evx054 (2017).
Lin Y, Golovnina K, Chen ZX, Lee HN, Negron YL, Sultana H, Oliver B, Harbison ST*. Comparison of normalization and differential expression analyses using RNA-Seq data from 726 individual Drosophila melanogaster. BMC genomics 17, 28, doi:10.1186/s12864-015-2353-z (2016).
Lin Y, Chen ZX, Oliver B, Harbison ST*. Microenvironmental Gene Expression Plasticity Among Individual Drosophila melanogaster. G3 6, 4197-4210, doi:10.1534/g3.116.035444 (2016).
Chen ZX & Oliver B*. X Chromosome and Autosome Dosage Responses in Drosophila melanogaster Heads. G3 5, 1057-1063, doi:10.1534/g3.115.017632 (2015).
Clough E, Jimenez E, Kim YA, Whitworth C*, Neville MC, Hempel L, Pavlou H, Chen ZX, Sturgill D, Dale R, Smith HE, Przytycka TM*, Goodwin SF*, Doren MV*, Oliver B*. Sex- and tissue-specific functions of Drosophila doublesex transcription factor target genes. Developmental cell 31, 761-773, doi:10.1016/j.devcel.2014.11.021 (2014).
Chen ZX#, Sturgill D#, Qu J, Jiang H, Park S, Boley N, Suzuki AM, Fletcher AR, Plachetzki DC, FitzGerald PC, Artieri CG, Atallah J, Barmina O, Brown JB, Blankenburg KP, Clough E, Dasgupta A, Gubbala S, Han Y, Jayaseelan JC, Kalra D, Kim YA, Kovar CL, Lee SL, Li M, Malley JD, Malone JH, Mathew T, Mattiuzzo NR, Munidasa M, Muzny DM, Ongeri F, Perales L, Przytycka TM, Pu LL, Robinson G, Thornton RL, Saada N, Scherer SE, Smith HE, Vinson C, Warner CB, Worley KC, Wu YQ, Zou X, Cherbas P, Kellis M, Eisen MB, Piano F, Kionte K, Fitch DH, Sternberg PW, Cutter AD, Duff MO, Hoskins RA, Graveley BR, Gibbs RA, Bickel PJ, Kopp A, Carninci P, Celniker SE, Oliver B*, Richards S. Comparative validation of the D. melanogaster modENCODE transcriptome annotation. Genome research 24, 1209-1223, doi:10.1101/gr.159384.113 (2014).
Chen ZX*, Golovnina K, Sultana H, Kumar S, Oliver B. Transcriptional effects of gene dose reduction. Biology of sex differences 5, 5, doi:10.1186/2042-6410-5-5 (2014).
Chen ZX, Zhang YE, Vibranovski M, Luo J, Gao G*, Long M*. Deficiency of X-linked inverted duplicates with male-biased expression and the underlying evolutionary mechanisms in the Drosophila genome. Molecular biology and evolution 28, 2823-2832, doi:10.1093/molbev/msr101 (2011).
发表数据集
Data
Golovnina K, Chen ZX, Lin Y, Sultana H, Oliver B, Harbison S, 2015. mRNA-Seq data of whole female/male individuals from 16 inbred Drosophila melanogaster DGRP lines. Gene Expression Omnibus GSE60314.
Chen ZX, Oliver B. 2015. mRNA-Seq of female, male, and sex-transformed Drosophila melanogaster heads from flies heterozygous for deletions on chromosome X and 3L. Gene Expression Omnibus GSE60571.
Chen ZX, Oliver B. 2015. CAGE-Seq of gonads and carcasses from D. melanogaster and D. pseudoobscura. Gene Expression Omnibus GSE66284.
Sturgill D, Chen ZX, Kopp A, Richards S, Oliver B. 2013. mRNA-Seq of whole adult females and males, and mixed sex embryos, from multiple Drosophila species. Gene Expression Omnibus GSE43321.
Oliver B, Chen ZX, Sturgill. 2013. New Drosophila pseudoobscura RNA-Seq coverage data. FlyBase.
发表社科文章
Research Report on Social sciences
龙漫远，陈振夏. 达尔文和他改变的世界.科学文化评论. 6(4): 13-26 (2009).
陈振夏. 大学生课外活动参与状况调查与研究.mgm4858am美高梅集团学报（社科版）, 5,6: 118-121 (2005).
其他发表文章
Other Publications
陈振夏. 果蝇的祖先天生双性恋？牛顿科学世界, (2010)
陈振夏. Y染色体少了，男人要没了？南都周刊, (2009)
陈振夏. 兴趣不是奢侈品. ——从喜欢花鸟虫鱼的日本皇子说起.科学时报, (2008).
Chen ZX. Genomics: A promising investment opportunity. BiotechBlog (2014).
陈振夏. 《在燕园留下的第一次》. 霍晓丹 编著. 《绚彩燕园青春北大——60位北大优秀毕业生的校园记忆》,北京大学出版社(2011).
本实验室动态（LAB NEWS）
实验室博客：http://blog.sciencenet.cn/u/chenzhenxia119
微信公众号“EvoDevo好好玩”，本实验室创建，内容包括演化发育基因组学领域的文献推荐、学习资源、技术博客、学术活动等。
QQ讨论群JC Bioinformatics（653435863），本实验室创建，面向全校生信爱好者，进行生物信息学技术交流和资源分享，并发布生物信息学兴趣小组线下活动通知。
