张德林 博士 副教授 硕士生导师
教育经历
2005-2011 武汉大学 生命科学院 生物化学与分子生物学专业 理学博士
1998-2002 mgm4858am美高梅集团 mgm4858am美高梅集团 微生物专业 理学学士
科研与工作经历
2017-至今 mgm4858am美高梅集团生科院 副教授
2014-2017 mgm4858am美高梅集团生科院 博士后
2011-2013 北京大学化学院（深圳研究生院） 博士后
2002-2005 武汉施瑞福生物技术有限公司 技术员
研究方向简介
1. 作物病虫害生物防治活性蛋白作用机制解析及应用
2. 作物遗传改良全国重点实验室、mgm4858am美高梅集团校级蛋白质平台技术支持
代表性研究成果
1. Jin X, Guan Z, Hu N, He C, Yin P, Gong Z* and Zhang D*. Structural insight into how WDR4 promotes the tRNA N7-methylguanosine methyltransferase activity of METTL1. Cell Discovery 2023 Jun 27; 9(1):65. doi: 10.1038/s41421-023-00562-y.
2. Wu Y#, Weng Z#, Yan H, Yao Z, Li Z, Sun Y, Ma K, Hull J, Zhang D*, Ma W*, Hua H and Lin Y. The microRNA-7322-5p/p38/Hsp19 axis modulates Chilo suppressalis cell-defences against Cry1Ca: an effective target for a stacked transgenic rice approach. Plant Biotechnology Journal. 2023 June 24. doi: 10.1111/pbi.14095.
3. Guo X#, Jiang Q#, Li Z, Cheng C, Feng Y, He Y, Zuo L, Ding W, Zhang D*, Feng L*. Crystal structural analysis and characterization for MlrC enzyme of Sphingomonas sp. ACM-3962 involved in linearized microcystin degradation. Chemosphere. 2023 Jan 12; 317:137866. doi:10.1016/j.chemosphere.2023.137866.
4. Cao B, Nie Y, Guan Z, Chen C, Wang N, Wang Z, Shu C, Zhang J*, Zhang D*. The crystal structure of Cry78Aa from Bacillus thuringiensis provides insights into its insecticidal activity. Communications Biology. 2022 August 09; 5(1):801. doi:10.1038/s42003-022-03754-6.
5. Zhou W, Guan Z, Zhao F, Ye Y, Yang F, Yin P, Zhang D*. Structural insights into dpCoA-RNA decapping by NudC. RNA Biology. 2021 Oct 15; 18(sup1):244-253. doi:10.1080/15476286.2021.1936837.
6. Wang Q#, Zhang D#, Guan Z, Li D, Pei K, Liu J, Zou T, Yin P*. DapF stabilizes the substrate-favoring conformation of RppH to stimulate its RNA-pyrophosphohydrolase activity in Escherichia coli. Nucleic Acids Research. 2018 Jul 27; 46(13):6880-6892. doi: 10.1093/nar/gky528.
7. Zhang D#, Liu Y#, Wang Q, Guan Z, Wang J, Liu J, Zou T, Yin P*. Structural basis of prokaryotic NAD-RNA decapping by NudC. Cell Research. 2016 Sep； 26(9):1062-1066. doi: 10.1038/cr.2016.98.
8. Shen C#, Zhang D#, Guan Z#, Liu Y, Yang Z, Yang Y, Wang X, Wang Q, Zhang Q, Fan S, Zou T, Yin P*. Structural basis for the specific single-stranded RNA recognition by designer pentatricopeptide repeat proteins. Nature Communications. 2016 Apr 18; 7:11285. doi: 10.1038/ncomms11285.
9. Wang X#, Feng J#, Xue Y#, Guan Z, Zhang D, Liu Z, Gong Z, Wang Q, Huang J, Tang C, Zou T, Yin P*. Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex. Nature. 2016 Jun 23; 534(7608):575-578. doi: 10.1038/nature18298.
10. Wang Q#, Guan Z #, Qi L#, Qi L, Zhuang J, Wang C, Hong S, Yan L, Wu Y, Cao X, Cao J, Yan J, Zou T, Liu Z, Zhang D, Yan C, Yin P*. Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex. Science. 2021 Sep 17. 373(6561):1377-1381. doi:10.1126/science.abh0704.
研究生招生方向
蛋白质结构与功能
联系方式
电子邮箱：zdl@mail.hzau.edu.cn
办公地点：作物遗传改良全国重点实验室（第二综合楼）A111-2室
