肖玉杰  博士  副研究员 硕导

科研与工作经历

2007.09～2011.07      本科    湖北大学生命科学学院

2011.09～2014.07      硕士    mgm4858am美高梅集团

2014.09～2017.07      博士    mgm4858am美高梅集团

2017.07～2021.10    博士后  mgm4858am美高梅集团

研究方向简介

细菌中第二信使c-di-GMP的功能及作用机制探究。主要针对c-di-GMP的代谢调控及c-di-GMP受体功能展开研究，揭示c-di-GMP对细菌生物被膜形成及瓦解的调控机制，以及对趋化性运动的调控机制。构建信号调控网络，阐明c-di-GMP信号系统在细菌感知/应对外界刺激中的作用。

基金项目：

(1) 国家自然科学基金委员会, 青年科学基金项目, 31900054, 恶臭假单胞菌KT2440中c-di-GMP合成酶WspR上游转录调节子的筛选和功能探究, 2020-01-01 至 2022-12-31, 在研, 主持。

(2) 中国博士后科学基金会, 中国博士后科学基金面上资助, 2018M642861, 恶臭假单胞菌中c-di-GMP受体FleQ功能探究及新受体筛选, 2019-01 至 2021-10, 结题, 主持。

研究成果：

1. Xiao Y, Liang Q, He M, Wu N; Nie L; Chen W; Huang Q. Second messenger c-di-GMP modulates exopolysaccharide Pea-dependent phenotypes via regulating eppA expression in Pseudomonas putida. Appl Microbiol Biot, 2022, 88: e02270-21.

2. Nie H^#, Xiao Y^#, Song M, Wu N, Peng Q, Duan W, Chen W, Huang Q. Wsp system oppositely modulates antibacterial activity and biofilm formation via FleQ-FleN complex in Pseudomonas putida. Environ Microbiol. 2022, doi: 10.1111/1462-2920.15905.（共同一作）

3. Xiao Y, Chen H, Nie L, He M, Peng Q, Zhu W, Nie H, Chen W, Huang Q. Identification of c-di-GMP/FleQ-regulated new target genes including cyaA encoding adenylate cyclase in Pseudomonas putida. mSystems, 2021, doi:10.1128/mSystems.00295-21.

4. Xiao Y, Nie L, Chen H, He M, Liang Q, Nie H, Chen W, Huang Q. The two-component system TarR-TarS is regulated by c-di-GMP/FleQ and FliA and modulates antibiotic susceptibility in Pseudomonas putida. Environ Microbiol, 2021, 23(9): 5239-5257.

5. Xiao Y, Liu H, He M, Nie L, Nie H, Chen W, Huang Q. A crosstalk between c-di-GMP and cAMP in regulating transcription of GcsA, a diguanylate cyclase involved in swimming motility in Pseudomonas putida. Environ Microbiol, 2019, 22(1): 142-157.

6. Xiao Y, Zhu W, He M, Nie H, Chen W, Huang Q. High c-di-GMP promotes expression of fpr-1 and katE involved in oxidative stress resistance in Pseudomonas putida KT2440. Appl Microbiol Biot, 2019, https: //doi.org/10.1007/s00253-019-10178-6.

7. Xiao Y, Zhu W, Liu H, Nie H, Chen W, Huang Q. FinR regulates expression of nicC and nicX operons involved in nicotinic acid degradation in Pseudomonas putida KT2440. App Environ Microbiol, 2018, doi: 10.1128/AEM.01210-18.

8. Xiao Y, Liu H, Nie H, Xie S, Luo X, Chen W, Huang Q. Expression of the phosphodiesterase BifA facilitating swimming motility is partly controlled by FliA in Pseudomonas putida KT2440. MicrobiologyOpen, 2017, 6: e00402.

9. Xiao Y, Nie H, Liu H, Luo X, Chen W, Huang Q. C-di-GMP regulates the expression of lapA and bcs operons via FleQ in Pseudomonas putida KT2440. Environ Microbiol Rep, 2016, 8: 659-666.

10. Xiao Y, Nie H, Liu H, Chen W, Huang Q. Expression of the diguanylate cyclase GcbA is regulated by FleQ in response to cyclic di-GMP in Pseudomonas putida KT2440. Environ Microbiol Rep, 2016, 8: 993-1002.

11. Xiao Y, Wang X, Chen W, Huang Q. Isolation and identification of three potassium-solubilizing bacteria from rape rhizospheric soil and their effects on ryegrass. Geomicrobiol J, 2017. http://dx.doi.org/10.1080/.1286416.

12. Nie H, Xiao Y, Liu H, He J, Chen W, Huang Q. FleN and FleQ play a synergistic role in regulating lapA and bcs operons in Pseudomonas putida KT2440. Environ Microbiol Rep, 2017, doi:10.1111/1758-2229.12547.

13. Liu H, Xiao Y, Nie H, Huang Q, Chen W. Influence of (p)ppGpp on biofilm regulation in Pseudomonas putida KT2440. Microbiol Res, 2017, 204:1–8.

14. Nie H, Xiao Y, He J, Liu H, Nie L, Chen W, Huang Q. Phenotypic-genotypic analysis of GGDEF/EAL/HD-GYP domain-encoding genes in Pseudomonas putida. Environ Microbiol Rep, 2019, doi: 10.1111/1758-2229.12808.

15. Liu H, Yan H, Xiao Y, Nie H, Huang Q, Chen W. The exopolysaccharide gene cluster pea is transcriptionally controlled by RpoS and repressed by AmrZ in Pseudomonas putida KT2440. Microbiol Res, 2019, doi: 10.1016/j.micres.2018.09.004.

联系方式

电子邮箱：yjxiao@mail.hzau.edu.cn

办公地点：农业微生物学国家重点实验室D座D401-1。