教育经历

1994-1998 湖南农业大学 食品科学技术学院 食品工程专业 工学学士学位

2000-2003 西南农业大学 资源与环境学院 微生物学专业 理学硕士学位

2003-2008 中国科学院沈阳应用生态研究所 微生物学专业 理学博士学位

科研与学术工作经历

2008-至今 mgm4858am美高梅集团 讲师，副教授

研究方向

从蛋白质-蛋白质相互作用及蛋白质-核酸相互作用出发，研究基因调控结核分枝杆菌生长及耐药相关的课题

代表性研究成果

论文

1. Liu Y, Wang H, Cui T, Zhou X, Jia Y, Zhang H*, He ZG*. (2016) NapM, a new nucleoid-associated protein, broadly regulates gene expression and affects mycobacterial resistance to anti-tuberculosis drugs.Mol Microbiol. 101, 167-181.

2. Zhang H, Zhang Z, Yang J, He ZG. (2014) Functional characterization of DnaB helicase and its modulation by single-stranded DNA-binding protein in Mycobacterium tuberculosis. FEBS J. 281, 1256-1266.

3. Zhang H, Gao L, Zhang J, Li W, Yang M, Zhang H, Gao C, He ZG. (2014) A novel marRAB operon contributes to the rifampicin resistance in Mycobacterium smegmatis.PloS One. 9, e106016.

4. Du Y, Zhang H, He Y, Huang F, He ZG. (2012) Mycobacterium smegmatis Lsr2 physically and functionally interacts with a new flavoprotein involved in bacterial resistance to oxidative stress. J Biochem. 152, 479-486.

5. Zhang H#, Tian Y#, Liu Z, Huang F, Hu L, He ZG. (2011) Characterization of amino acid residues essential for tetramer formation and DNA-binding activity of ssDNA-binding protein of Mycobacterium tuberculosis. Biochemistry (Mosc). 76, 658-665.

6. Sun L, Zhang L, Zhang H, He ZG. (2011) Characterization of a bifunctional β-Lactamase/Ribonuclease and its interaction with a chaperone-like protein in the pathogen Mycobacterium tuberculosis H37Rv. Biochemistry (Mosc). 76, 350-358.

7. Wang Y, Cui T, Zhang C, Yang M, Huang Y, Li W, Zhang L, Gao C, He Y, Li Y, Huang F, Zeng J, Huang C, Yang Q, Tian Y, Zhao C, Chen H, Zhang H, He ZG. (2010) Global protein-protein interaction network in the human pathogen Mycobacterium tuberculosis H37Rv. J. Proteome. Res. 9, 6665–6677.

8. Li Y, Zeng J, Zhang H, He ZG. (2010) The characterization of conserved binding motifs and potential target genes for M. tuberculosis MtrAB reveals a link between the two-component system and the drug resistance of M. smegmatis. BMC Microbiol.10, 242.

9. Yang M, Gao C, Wang Y, Zhang H, He ZG. (2010) Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules. PLoS One, e10672.

10. Zhang H, Bi L, Li C, Sun Z, Deng J, Zhang XE. (2009) Mutations found in the pncA gene of Mycobacterium tuberculosis in clinical pyrazinamide-resistant isolates from a local region of China. J. Int. Med. Res. 37, 1430-1435.

11. Zhang H, Deng J, Bi L, Zhou Y, Zhang Z, Zhang C, Zhang Y. Zhang XE. (2008) Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase. FEBS J. 275, 753-762.

获得奖励

2012-2014年获mgm4858am美高梅集团教学质量三等奖

主讲课程

微生物学基础、普通微生物学实验

研究生招生专业

微生物致病信号网络与新药靶标

联系方式

实验室电话：027-87284295

电子邮箱：zhanghua@mail.hzau.edu.cn

办公地点：农业微生物国家重点实验室外三楼202

实验室介绍及网址：