徐纬 博士 副研究员

教育经历

2007-09 至 2011-06 武汉大学药学院 攻读药学专业学士学位

2011-09 至 2017-06 武汉大学药学院 攻读生物化学与分子生物学博士学位

工作经历

2017-07至2018-12 武汉大学 药学院 研究助理

2019-02至2020-04 新加坡科技研究局 化学科学与工程研究所 科学家I

2020-04至2022-01 新加坡科技研究局 食品与生物工程创新研究所 科学家I

2022-02至今  mgm4858am美高梅集团 mgm4858am美高梅集团 副研究员

研究方向

1. 微生物基因编辑技术的开发与应用

2. 微生物来源天然产物生物合成途径的挖掘与解析

研究生招生方向

生物工程、微生物学

联系方式

xuw@@mail.hzau.edu.cn [请手动删去一个@]

mgm4858am美高梅集团第一综合楼A401

发表论文

1. Wei Xu, Guifa Zhai, Yuanzhen Liu, Yuan Li, Yanrong Shi, Kui Hong, Hui Hong, Peter F. Leadlay, Zixin Deng, and Yuhui Sun. 2017. “An Iterative Module in the Azalomycin F Polyketide Synthase Contains a Switchable Enoylreductase Domain.” Angewandte Chemie International Edition 56 (20): 5503–6. https://doi.org/10.1002/anie.201701220.

2. Wei Xu, Evaldas Klumbys, Ee Lui Ang, and Huimin Zhao. 2020. “Emerging Molecular Biology Tools and Strategies for Engineering Natural Product Biosynthesis.” Metabolic Engineering Communications 10 (June): e00108. https://doi.org/10.1016/j.mec.2019.e00108.

3. Yanling Ma, Wei Xu, Jun Zhang, Sihong Zhang, Kui Hong, Zixin Deng, and Yuhui Sun. 2014. “Nitrilase Superfamily Aryl Acylamidase from the Halotolerant Mangrove Streptomyces Sp. 211726.” Applied Microbiology and Biotechnology 98 (20): 8583–90. https://doi.org/10.1007/s00253-014-5762-z.

4. Hu Zeng, Shishi Wen, Wei Xu, Zhaoren He, Guifa Zhai, Yunkun Liu, Zixin Deng, and Yuhui Sun. 2015. “Highly Efficient Editing of the Actinorhodin Polyketide Chain Length Factor Gene in Streptomyces coelicolor M145 Using CRISPR/Cas9-CodA(sm) Combined System.” Applied Microbiology and Biotechnology 99 (24): 10575–85. https://doi.org/10.1007/s00253-015-6931-4.

5. Guifa Zhai, Wenyan Wang, Wei Xu, Guo Sun, Chaoqun Hu, Xiangming Wu, Zisong Cong, et al. 2020. “Cross-Module Enoylreduction in the Azalomycin F Polyketide Synthase.” Angewandte Chemie International Edition 59 (50): 22738–42. https://doi.org/10.1002/anie.202011357.

6. Yuanzhen Liu, Xu Chen, Zhengyuan Li, Wei Xu, Weixin Tao, Jie Wu, Jian Yang, Zixin Deng, and Yuhui Sun. 2017. “Functional Analysis of Cytochrome P450s Involved in Streptovaricin Biosynthesis and Generation of Anti-MRSA Analogues.” ACS Chemical Biology 12 (10): 2589–97. https://doi.org/10.1021/acschembio.7b00467.

7. Chunhua Zhao, Jianzhao Qi, Weixing Tao, Lei He, Wei Xu, Jason Chan, and Zixin Deng. 2014. “Characterization of Biosynthetic Genes of Ascamycin/Dealanylascamycin Featuring a 5′-O-Sulfonamide Moiety in Streptomyces sp. JCM9888.” PLoS One 9 (12): e114722. https://doi.org/10.1371/journal.pone.0114722.

8. Zhiyu Zhong, Junhong Guo, Liang Deng, Li Chen, Jian Wang, Sicong Li, Wei Xu, Zixin Deng, and Yuhui Sun. 2019. “Base Editing in Streptomyces with Cas9-deaminase Fusions.” bioRxiv, 630137. https://doi.org/10.1101/630137.