Professor

Email: hejin@mail.hzau.edu.cn

Tel: 86-27-87280670

Research Interest:

    Our research interests include microbial functional genomics, the function of bacterial nucleotide second messenger molecules and non-coding RNA, as well as the global  regulation of bacterial metabolism. In recent years, the research direction has gradually expanded to include the aspects of synthetic biology and intestinal microorganisms.  The main research directions now include: (1) Starting from the basic theoretical research on the nucleotide second messenger molecules of c-di-GMP and c-di-AMP to reveal their regulatory mechanism on the physiological functions of bacteria to lay basis for the application of beneficial microorganisms and prevention and control of harmful microorganisms; (2) Studying the regulatory mechanism of non-coding RNA, such as anti-sense RNA, 6S RNA, and tmRNA, to lay the foundation for the transformation and utilization of bacteria; (3) Developing various synthetic biological regulatory elements; (4) Studying related intestinal microbial flora and colorectal cancer.

Education: 

09/1985-06/1989: Bachelor of Science in Agriculture (Agricultural Chemistry) at College of Resources and Environment,

                              Huazhong Agricultural University Wuhan, Hubei, China.

09/1991-06/1994: Master of Science in Agriculture (Food Science) at College of Food Science and Technology,

                             Huazhong Agricultural University Wuhan, Hubei, China.

09/1999-06/2003: Doctor of Science (Microbiology) at College of Life Science and Technology,

                              Huazhong Agricultural University Wuhan, Hubei, China.

Professional Experiences:

07/1989-08/1991: Technician, Wuhan Shuangfeng Citric Acid Co., Ltd., Wuhan, Hubei, China.

01/2010-Present:  Lecturer, Associate Professor, and Professor (Level 3), College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China.

12/2006-03/2008:  Postdoc/Visiting Scholar, Department of Microbiology, University of Illinois at Urbana-Champaign, Illinois, USA.

Selected Publications:

[1]     Wen Yin, Xia Cai, Hongdan Ma, Li Zhu, Yuling Zhang, Shan-Ho Chou, Michael Galperin, Jin He*. A decade of research on the second messenger c-di-AMP. FEMS Microbiology Reviews, 2020, 44, doi: 10.1093/femsre/fuaa019.

[2]     Jin He^#,* , Wen Yin^#, Michael Y. Galperin^*, Shan-Ho Chou^*. Cyclic di-AMP, a second messenger of primary importance: tertiary structures and binding mechanisms. Nucleic Acids Research, 2020, 48(6):2807–2829.

[3]     Siyang Xu^#, Wen Yin^#, Yuling Zhang, Qimei Lv, Yijun Yang, Jin He^*. Foes or friends? Bacteria enriched in the tumor microenvironment of colorectal cancer. Cancers, 2020, 12(2): 00372.

[4]     Cao Zheng, Zhaoqing Yu, Cuiying Du, Yujing Gong, Wen Yin, Xinfeng Li, Zhou Li, Ute Römling, Shan-Ho Chou, Jin He^*. 2-Methylcitrate cycle: a well-regulated controller of Bacillus sporulation. Environmental Microbiology, 2020(3): 1125–1140.

[5]     Xun Wang, Xia Cai, Hongdan Ma, Wen Yin, Li Zhu, Xinfeng Li, Heon M. Lim, Shan-Ho Chou, Jin He^*. A c-di-AMP riboswitch controlling kdpFABC operon transcription regulates the potassium transporter system in Bacillus thuringiensis. Communications Biology, 2019, 2:151.

[6]     Yang Fu, Zhaoqing Yu, Shu Liu, Bo Chen, Li Zhu, Zhou Li, Shan-Ho Chou, Jin He^*. C-di-GMP regulates various phenotypes and insecticidal activity of Gram-positive Bacillus thuringiensis. Frontiers in Microbiology, 2018, 9: 0045. (recommended as the F1000Prime paper)

[7]     Xinfeng Li^#, Han Mei^#, Fang Chen, Qing Tang, Zhaoqing Yu, Xiaojian Cao, Binda Tembeng Andongma, Shan-Ho Chou, Jin He^*. Transcriptome landscape of Mycobacterium smegmatis. Frontiers in Microbiology, 2017, 8: 2505.

[8]     Maria Kanwal Ali, Xinfeng Li, Qing Tang, Xiaoyu Liu, Fang Chen, Jinfeng Xiao, Muhammad Ali, Shan-Ho Chou, Jin He^*. Regulation of inducible potassium transporter KdpFABC by KdpD/KdpE two-component system in Mycobacterium smegmatis. Frontiers in Microbiology, 2017, 8: 570.

[9]     Hang Zhou^#, Cao Zheng^#, Jianmei Su^#, Bo Chen, Yang Fu, Yuqun Xie, Qing Tang, Shan-Ho Chou, Jin He^*. Characterization of a natural triple-tandem c-di-GMP riboswitch and application of the riboswitch-based dual-fluorescence reporter. Scientific Reports, 2016, 6: 20871.

[10] Cao Zheng, Yang Ma, Xun Wang, Yuqun Xie, Maria Kanwal Ali, Jin He^*. Functional analysis of the sporulation-specific diadenylate cyclase CdaS in Bacillus thuringiensis. Frontiers in Microbiology, 2015, 6: 908.

[11] Qing Tang, Yunchao Luo, Cao Zheng, Kang Yin, Maria Kanwal Ali, Xinfeng Li, Jin He^*. Functional analysis of a c-di-AMP-specific phosphodiesterase MsPDE from Mycobacterium smegmatis. International Journal of Biological Sciences, 2015, 11(7): 813-824.

[12] Qing Tang, Xinfeng Li, Tingting Zou, Huimin Zhang, Yingying Wang, Rongsui Gao, Zhencui Li, Jin He^*, Youjun Feng*. Mycobacteria smegmatis BioQ defines a new regulatory network for biotin metabolism. Molecular Microbiology, 2014, 94 (5): 1006-1023.

[13] Shumeng Zhang, Jieping Wang, Yale Wei, Qing Tang, Maria Kanwal Ali, Jin He^* Heterologous expression of VHb can improve the yield and quality of biocontrol fungus Paecilomyces lilacinus, during submerged fermentation. Journal of Biotechnology, 2014, 187, 147-153.

[14] Jianmei Su, Lin Deng, Liangbo Huang, Shujin Guo, Fan Liu and Jin He^*. Catalytic oxidation of manganese (II) by multicopper oxidase CueO and characterization of the biogenic Mn oxide. Water Research, 2014, 56, 304-313.

[15] Jieping Wang, Han Mei, Cao Zheng, Hongliang Qian, Cui Cui, Yang Fu, Jianmei Su, Ziduo Liu, Ziniu Yu, Jin He^*. The metabolic regulation of Bacillus thuringiensis for the formation of spores and parasporal crystals revealed by the transcriptomics and proteomics. Molecular and Cellular Proteomics, 2013, 12(5): 1363-1376.