张敏 博士 教授

教育经历

1998-2002 mgm4858am美高梅集团水产学院 淡水渔业 理学学士学位

2003-2008 中科院水生生物研究所 水生生物学 理学博士学位

科研与学术工作经历

2015-至今 mgm4858am美高梅集团 mgm4858am美高梅集团 教授

2009-2015 加州大学戴维斯分校 兽医学院 博士后

2008-2009 中科院水生生物研究所 蛋白质工程 助理研究员

研究方向

RNA结合蛋白在器官发育与癌症发生中作用与机制

代表性研究成果

论文¹

1.Zhang, M., Zhang, J., Yan, W. & Chen, X. p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability. Oncotarget 7, 78255-78268, doi:10.18632/oncotarget.13126 (2016).

2.Zhang, M., Xu, E., Zhang, J. & Chen, X. PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38. Oncogene 34, 5900-5911, doi:10.1038/onc.2015.31 (2015).

3.Zhang, M.,Zhang, J.,Chen, XL.,Cho, SJ.,Chen, XB. (2013) Glycogen synthase kinase 3 promotes p53 mRNA translation via phosphorylation of RNPC1. Genes & Development 27(20): 2246-2258.

4.Zhang, M., Zhang, C., Li, J., Hanna, M., Zhang, X., Dai, H. and Xiao, W. (2011) Inactivation of YAP1 enhances sensitivity of the yeast RNR3-lacZ genotoxicity testing system to a broad range of DNA-damaging agents. Tox. Sci. 120: 310-321.

5.Zhang, M., Hanna, M., Li, J., Butcher, S., Dai, H. and Xiao, W. (2010) Creation of a hyperpermeable yeast strain to genotoxic agents through combined inactivation of PDR and CWP genes. Tox. Sci. 113: 401-411.

6.Zhang, M., Liang, Y., Zhang, X., Xu, Y., Dai, H. and Xiao, W. (2008) Deletion of yeast CWP genes enhances cell permeability to genotoxic agents. Toxicol. Sci. 103: 68-76.

7. Zhang, J., Xu, EX., Cong, R., Yang,WS.,Zhang, M., Chen, MY., Cardiffd, R., Imaie D., Wisnerb, E., Chen XB. (2014) Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors. Proc Natl Acad Sci U S A 111(52): 18637-18642.

8. Jiang, Y. Q.,Zhang, M; Qian, Yingjuan; et al (2014) Rbm24, an RNA-binding Protein and a Target of p53, Regulates p21 Expression via mRNA Stability. Journal of Biological Chemistry 289(6): 3164-3175.

9. Xu, Enshun; Zhang, Jin;Zhang, Min; et al. (2014) RNA-Binding Protein RBM24 Regulates p63 Expression via mRNA Stability. Molecular Cancer Research 12(3): 359-369.

10.Cho, SJ.,Rossi, A.,Jung, YS.,Yan, WS.,Liu, G.,Zhang, J.,Zhang, M.,Chen, XB. (2013) Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality. Proceedings of the National Academy of Sciences of the United States of America 110(23): 9362-9367.

11. Chen, X. L.,Zhang, J.,Zhang, M.,Liu, S.,Yan, WS.,Jung, JH.,Chen, XB. (2012) Serine 123 Phosphorylation Modulates p21 Protein Stability and Activity by Suppressing Ubiquitin-independent Proteasomal Degradation. Journal of Biological Chemistry 287(41): 34410-34418.

12. Dai, H.,Zhang, M., Zhang, C., Wei, T., Xu, Y., and Xiao, W. （2011）Developing sensitive assessment system for environmental chemical carcinogens detection Curr. Opin. Biotechnol. 22, Supplement 1, S71.

13. Wang, Y., Zhang, X., Xiao, N.Zhang, M., Dai, H. Selection of a novel single-chain variable fragment antibody specifically against a linear epitope of white spot syndrome virus. Sheng Wu Gong Cheng Xue Bao, 2008, 24(8): 1387-94.

14. 杨毅;张敏;袁丽;张晓华;戴和平;.抗对虾白斑综合症病毒单链抗体P1D3基因在毕赤酵母中的分泌表达,生物工程学报,2006,22(6):973-978

授权专利

所有专利权人，专利名称，授权日期，中国（美国），专利号ZL201210137450.6。

戴和平,肖伟，张敏,张晓华, 可用于检测环境致癌物的高通透性面包酵母及其制备方法20080813 中国 CN101240251A

戴和平,肖伟，张敏,张晓华, 一种超高通透性面包酵母及其制备方法 20110713 中国 CN200910272505.2

戴和平,肖伟，张超，张敏,张晓华,一种对氧化损伤高敏感性的面包酵母及其制备方法 20130619 中国CN102120968A

其他成果

获得奖励

主讲课程

发育生物学

研究生招生专业

发育生物学

联系方式

实验室电话：

电子邮箱：minzhang@mail.hzau.edu.cn

办公地点：基因楼414

实验室介绍及网址：