李兴旺  中共党员  博士   教授   博士生导师   

教育经历（从大学本科开始）:

1999.9-2003.7 内蒙古农业大学 生物工程学院 生物技术专业 理学学士学位

2003.9-2011.3 mgm4858am美高梅集团 mgm4858am美高梅集团 生物化学与分子生物学专业 理学博士学位

科研与学术工作经历:

2016.8-现在  mgm4858am美高梅集团 生命科学与技术学院 作物遗传与改良国家重点实验室 教授

2013.7-2016.7  The Jackson Laboratory for Genomic Medicine 博士后

2011.7-2013.6 mgm4858am美高梅集团 作物遗传与改良国家重点实验室 Research Associate

研究方向:

      真核生物的线性基因组在细胞核内组织成一定的三维空间结构，在基因转录调控和个体发育中发挥重要作用。我们课题组主要开发和利用多种技术手段，  在不同空间和时间尺度下鉴定参与水稻三维基因组结构的DNA，RNA和蛋白质的空间组织形式及其动态变化；揭示其参与基因转录调控进而影响重要农艺性状的机理。课题组的远期目标是运用CRISPR及其多种衍生技术，人工改造水稻的表观遗传修饰和顺式调控元件的远程相互作用，进行作物遗传改良。

代表性研究论文（*共同第一作者；#共同通讯作者）:

26. Qin Xiao*, Xingyu Huang*, Yan Zhang, Wei Xu, Yongqing Yang, Qing Zhang, Zhe Hu, Feng Xing, Qianwen Sun, Guoliang Li, Xingwang Li. The landscape of promoter-centered RNA-DNA interactions in rice. Nature Plants, 2022, 157–170.

25. Li Deng*, Baibai Gao*, Lun Zhao, Ying Zhang, Qing Zhang, Guoting Chen, Shuangqi Wang, Liang Xie, C. Robertson McClung, Guoliang Li, Xingwang Li. The landscapes of diurnal epigenome and 3D genome architecture in rice. Genome Biology, 2022, 23: 7.

24. Weizhi Ouyang*, Shiping Luan*, Xu Xiang, Minrong Guo, Yan Zhang, Guoliang Li, Xingwang Li. Profiling Plant Histone Modification at Single-cell Resolution. Plant Biotechnology Journal, 2022, https://doi.org/10.1111/pbi.13768

23. Liang Xie, Minghao Liu, Lun Zhao, Kai Cao, Peng Wang, Wenhao Xu, Wing-Kin Sung, Xingwang Li#, Guoliang Li#. RiceENCODE: a comprehensive epigenomic database as rice Encyclopedia of DNA Elements. Molecular Plant, 2021, 14 :1604–1606

      22. Weizhi Ouyang, Xiwen Zhang, Yong Peng, Qing Zhang, Zhilin Cao, Guoliang Li, Xingwang Li. Rapid and low-input profiling of histone marks in plants

using nucleus CUT&Tag. Frontiers in Plant Science, 2021, 12: 634679

21.Qing Zhang*, Pengpeng Guan*, Lun Zhao*, Meng Ma, Liang Xie, Yue Li, Ruiqin Zheng, Weizhi Ouyang, Shunyao Wang, Hongmeijuan Li, Ying Zhang, Yong Peng, Zhilin Cao, Wei Zhang, Qin Xiao, Yuanling Xiao, Tingdong Fu, Guoliang Li#, Xingwang Li# , Jinxiong Shen# (2021) Asymmetric epigenome maps of subgenomes reveal imbalanced transcription and distinct evolutionary trends in Brassica napus. Molecular Plant. 14:604–619

20. Weizhi Ouyang*, Qin Xiao*, Guoliang Li^#, Xingwang Li^# (2021) Technologies for Capturing 3D Genome Architecture in Plants. Trends in Plant Science. 26: 196–197

19. Weizhi Ouyang*, Dan Xiong*, Guoliang Li^#, Xingwang Li^# (2020) Unraveling the 3D Genome Architecture in Plants: Present and Future. Molecular Plant. 13: 1676–1693

18. Weizhi Ouyang*, Zhilin Cao*, Dan Xiong, Guoliang Li^#, Xingwang Li^# (2020) Decoding the Plant Genome: from Epigenome to 3D Organization. Journal of Genetics and Genomics. 47: 425–435

17. Lun Zhao*, Liang Xie*, Qing Zhang*, Weizhi Ouyang, Li Deng, Pengpeng Guan, Meng Ma, Yue Li, Ying Zhang, Qin Xiao, Jingwen Zhang, Hongmeijuan Li, Shunyao Wang, Jiangwei Man, Zhilin Cao, Qinghua Zhang, Qifa Zhang, Guoliang Li^#, Xingwang Li^# (2020) Integrative analysis of reference epigenomes in 20 rice varieties. Nature Communications. 11: 2658.

16. Yonghao Sun*, Liang Dong*, Ying Zhang, Da Lin, Weize Xu, Changxiong Ke, Linqian Han, Lulu Deng, Guoliang Li, David Jackson, Xingwang Li^#, Fang Yang^# (2020) 3D genome architecture coordinates trans and cis regulation of differentially expressed ear and tassel genes in maize. Genome Biology. 21: 143.

15. Lun Zhao*, Shuangqi Wang*, Zhilin Cao*, Weizhi Ouyang, Qing Zhang, Liang Xie, Ruiqin Zheng, Minrong Guo, Meng Ma, Zhe Hu, Wing-Kin Sung, Qifa Zhang, Guoliang Li^#, Xingwang Li^# (2019) Chromatin loops associated with active genes and heterochromatin shape rice genome architecture for transcriptional regulation. Nature Communications. 10: 3640.

14. Yong Peng*, Dan Xiong*, Lun Zhao, Weizhi Ouyang, Shuangqi Wang, Jun Sun, Qing Zhang, Pengpeng Guan, Liang Xie, Wenqiang Li, Guoliang Li^#, Jianbing Yan^#, Xingwang Li^# (2019) Chromatin Interaction Maps Reveal Genetic Regulation for Quantitative Traits in Maize. Nature Communications. 10: 2632.

13. Xingwang Li*, Oscar Luo*, Ping Wang, Meizhen Zheng, Danjuan Wang, Emaly Piecuch, Jacqueline Jufen Zhu, Simon Tian, Zhonghui Tang, Guoliang Li, Yijun Ruan. (2017) Long-read ChIA-PET for base-pair resolution mapping of haplotype-specific chromatin interactions. Nature Protocol. 12: 899–915.(*Co-first author)

12. Zhonghui Tang*, Oscar Luo*, Xingwang Li*, Meizhen Zheng, Jacqueline Jufen Zhu, Przemyslaw Szalaj, Pawel Trzaskoma, Adriana Magalska, Jakub Wlodarczyk, Blazej Ruszczycki, Paul Michalski, Emaly Piecuch, Ping Wang, Danjuan Wang, Simon Zhongyuan Tian, Xiaoan Ruan, May Penrad-Mobayed, Laurent M. Sachs, Chia-Lin Wei, Edison T. Liu, Grzegorz M. Wilczynski, Dariusz Plewczynski, Guoliang Li, Yijun Ruan. (2015) CTCF-mediated 3D genome architecture reveals a chromatin topology for transcription regulation. Cell. 163: 1611–1627. (*Co-first author)

11. Xingwang Li and Changyin Wu. (2014) Rice Meiotic Chromosome Spread Preparation of Pollen Mother Cells. Bio-protocol 4(14): e1189.

10. Xingwang Li, Yuxiao Chang, Xiaodong Xin, Chunmei Zhu, Xianghua Li, James D Higgins, Changyin Wu. (2013) Replication Protein A2c Coupled with Replication Protein A1c Regulates Crossover Formation during Meiosis in Rice. Plant Cell. 25: 3885–3899.

9. Xingwang Li, Xingqiang Gao, Yi Wei, Li Deng, Yidan Ouyang, Guoxing Chen, Xianghua Li, Qifa Zhang, Changyin Wu. (2011) Rice Apoptosis inhibitor 5 coupling with two DEAD-box ATP-dependent RNA helicases regulates the PCD process of tapetum degeneration. Plant Cell. 23:1416–1434.

8. Laura Vian, Aleksandra Pekowska, Suhas Rao, Kyong-Rim Kieffer-Kwon, Seolkyoung Jung, Laura Baranello, Su-Chen Huang, Laila El Khattabi, Marei Dose, Nathanael Pruett, Adrian Sanborn,  Andres Canela, Yaako Maman, Anna Oksanen, Wolfgang Resch, Xingwang Li, Byoungkoo Lee, Alexander Kovalchuk, Zhonghui Tang, Steevenson Nelson, Pierro Di, Cheng Michele, Machol Ryan, Ido St Hilaire, Glenn Brian, Neva Durand, Muhammad Shamim, Elena Stamenova, Jose Onuchic, Yijun Ruan, Andre Nussenzweig, David Levens, Erez Lieberman Aiden, Rafael Casellas. (2018) The Energetics and Physiological Impact of Cohesin Extrusion. Cell.173: 1165–1178.

7. Peng Li, Suman Mitra, Rosanne Spolski, Jangsuk Oh, Wei Liao, Zhonghui Tang, Fei Mo, Xingwang Li, Erin West, Daniel Gromer, Jian-Xin Lin, Chengyu Liu, Yijun Ruan, Warren Leonard. (2017) STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus. Proc Natl Acad Sci U S A. 114:12111–12119.

6. Isis Ricano-Ponce, Daria Zhernakova, Patrick Deelen, Oscar Luo, Xingwang Li, Aaron Isaacs, Juha Karjalainen, Jennifer Di Tommaso, Zuzanna Agnieszka Borek, Maria Zorro, Javier Gutierrez-Achury, Andre Uitterlinden, Albert Hofman, Joyce van Meurs, Mihai Netea, Iris Jonkers, Sebo Withoff, Cornelia van Duijn, Yang Li, Yijun Ruan, Lude Franke, Cisca Wijmenga, Vinod Kumar. (2016) Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs. J Autoimmun. 68:62–74.

5. Przemyslaw Szalaj, Zhonghui Tang, Paul Michalski, Michal Pietal, Oscar Luo, Michal Sadowski, Xingwang Li, Kamen Radew, Yijun Ruan, Dariusz Plewczynski. (2016) An integrated 3-Dimensional Genome Modeling Engine for data-driven simulation of spatial genome organization. Genome Res. 26: 1697–1709.

4. Xinqiang Gao, Zhihui Chen, Jian Zhang, Xingwang Li, Guoxing Chen, Xianghua Li, Changyin Wu. (2012) OsLIS-L1 encoding a lissencephaly type-1-like protein with WD40 repeats is required for plant height and male gametophyte formation in rice. Planta. 353: 713–727.

3. Yuxiao Chang, Liang Gong, Wenya Yuan, Xingwang Li, Guoxing Chen, Xianghua Li, Qifa Zhang, Changyin Wu. (2009) Replication protein A (RPA1a) is required for meiotic and somatic DNA repair but is dispensable for DNA replication and homologous recombination in rice. Plant Physiol. 15: 2162–2173.

2. Wenya Yuan, Xingwang Li, Yuxiao Chang, Ruoyu Wen, Guoxing Chen, Qifa Zhang, Changyin Wu. (2009) Mutation of the rice gene PAIR3 results in lack of bivalent formation in meiosis. Plant J. 59: 303–315.

1. Jian Zhang, Dong Guo, Yuxiao Chang, Changjun You, Xingwang Li, Xiaoxia Dai, Qijun Weng, Guoxing Chen, Qifa Zhang, Changyin Wu. (2007) Non-random distribution of T-DNA insertions at various levels of the genome hierarchy as revealed by analyzing 13804 T-DNA flanking sequences from an enhancer-trap mutant library. Plant J. 49: 947–959.

主讲课程

生信信息学；生命科学导论MOOC；分子克隆技术；表观基因组学

研究生招生专业

基因组学；生物化学与分子生物学

联系方式

实验室电话：

电子邮箱：xingwangli@mail.hzau.edu.cn

办公地点：作物遗传改良国家重点实验室（第二综合楼）B613-1

实验室介绍及网址：课题组将培养同时具备多种实验设计和操作技能及高通量组学数据处理和分析能力的新一代科学家。欢迎对课题组研究方向感兴趣的研究生、博士后和科研助理加入。